What is Megaderm®?
Megaderm has been developed to optimise the synergistic effects of Omega 6 and Omega 3. It is an Essential Fatty acid supplement for dogs and cats.
How does Megaderm differ from EFA –Z?
Megaderm is a more focused option to consider for managing pruritus. Megaderm contains a 5:1 ratio of Omega 6 to Omega 3. There is expert opinion supporting that this is the appropriate ratio. Much more Omega 3 is required than in EFA-Z to influence the inflammatory cascade. EFA-Z has a ratio of 40:1 Omega 6 to Omega 3 so it is more focused on keeping coat quality maintained and preventing seborrhoea.
How does Megaderm® influence inflammatory skin conditions?
Megaderm limits the outcome of the inflammatory processes by modifying EFA metabolism in the skin. This influences the metabolic pathways of Poly-unsaturated fatty acids (PUFAs) that are involved in the inflammatory cascade. Activity is achieved by depriving the inflammatory process of its initial substrate (the arachidonic acid, W 6), inhibiting its potential metabolic conversions, and diverting the metabolic pathways towards fatty acids that will produce anti-inflammatory (or less inflammatory) mediators instead of pro-inflammatory mediators.
Why use Omega 6 and Omega 3?
The synergistic effects of W 6 and W 3 EFAs are beneficial as well in restoring skin integrity and providing an anti-inflammatory effect, by the control of PUFAs metabolic pathways.
Omega 6 are well described for maintaining good coat quality by maintaining water balance and cell integrity, modifying cell proliferation, and maintaining lustre whilst minimising seborrhoea.
In contrast Omega 3 has limited specific coat quality activity but is a key influencer of the inflammatory cascade.
Directions for use?
(for 1L bottle, follow directions on pack)
1. Use 4mL sachet for pets up to 10kg,
Use 8mL sachet for pets 10 to 20kg
Use 2 x 8mL sachets for pets over 20kg.
2. Give once a day for dermatological conditions or once every 2nd day for maintaining healthy skin and coat.
3. Cut along perforation.
4. Squeeze contents onto your pet’s usual food and mix through.
This product has recently undergone a packaging change. Customers may receive old packaging during this transition.